Research

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Research · 01

DNA Nanotechnology

AI-Driven DNA/RNA Nanostructure Design
Dynamic DNA Origami & Molecular Machines
Programmable Nucleic Acid Therapeutics (mRNA/CRISPR Delivery)
Hierarchical Self-assembly for Smart Materials

Featured Research

Computer-aided design software and simulation tools for DNA nanoparticles

Advanced Materials Technologies, 11(4):e00438 Article

Trinh, M.C., Jun, H.†

IF 6.2 2026. 2.

Classification of DNA Nanoparticle CAD Software

This review chronologically examines computer-aided design (CAD) software designed to overcome limitations of manual design. It categorizes design methodologies into bottom-up and top-down strategies, encompassing tile-based and frame-based architectures.

Simulation Methodologies and Future Prospects

The study classifies simulation tools into finite-element and coarse-grained molecular dynamics models. It highlights future needs, including unified automation platforms and deep learning integration to conserve time and effort.

Programming 2D Supramolecular Assemblies with Wireframe DNA Origami

Journal of the American Chemical Society, 144: 4403-9 Article

Wang, X., Jun, H., Bathe

IF 16.4 JCR Top 8.7% 2022. 3.

Selected Publications

2026

Computer-aided design software and simulation tools for DNA nanoparticles

Trinh, M.C., Jun, H.†

Advanced Materials Technologies, 11(4):e00438 · 2026. 2. 19.

IF 6.2 Article
2022

Programming 2D Supramolecular Assemblies with Wireframe DNA Origami

Wang, X., Jun, H., Bathe

Journal of the American Chemical Society, 144: 4403-9 · 2022. 3. 16.

IF 16.4 JCR Top 8.7% Article
2019

Automated sequence design of 2D wireframe DNA origami with honeycomb edges

Jun, H.*, Wang, X., Bricker, W., Bathe, M.

Nature Communications, 10: 5419 · 2019. 11. 16.

IF 17.7 JCR Top 7.4% Article
2019

Automated sequence design of 3D polyhedral wireframe DNA origami with honeycomb edges

Jun, H.*, Shepherd, T., Zhang, K., Bricker, W., Li, S., Chiu W., Bathe, M.

ACS Nano, 13: 2083-93 · 2019. 1. 16.

IF 18.0 JCR Top 5.7% Article
2019

Autonomously designed free-form 2D DNA origami

Jun, H.*, Zhang, F., Ratanalert, S., Shepherd, T., Qi, X., Yan, H., Bathe, M.

Science Advances, 5: eaav0655 · 2019. 1. 16.

IF 15.0 JCR Top 8.8% Article